SOCS1 polyclonal antibody
产品名称： SOCS1 polyclonal antibody
英文名称： SOCS1 polyclonal antibody
产品编号： PAB12778
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of SOCS1.
- Immunogen:
- A synthetic peptide corresponding to C-terminus of human and mouse SOCS1.
- Host:
- Rabbit
- Theoretical MW (kDa):
- 24
- Reactivity:
- Human, Mouse
- Specificity:
- This antibody recognizes ~24 KDa of SOCS1.
- Form:
- Liquid
- Storage Buffer:
- In PBS, pH 7.2 (10% Proclin300)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Western Blot (0.1-1 ug/mL)
ELISA (0.01-0.1 ug/mL)
Immunoprecipitation (2-5 ug/mL)
Immunohistochemistry (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.
- Publication Reference
- 1.
- IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia.
Qin H, Wilson CA, Lee SJ, Benveniste EN.FASEB J. 2006 May;20(7):985-7. Epub 2006 Mar 29.
- Entrez GeneID:
- 8651
- Gene Name:
- SOCS1
- Gene Alias:
- CIS1,CISH1,JAB,SOCS-1,SSI-1,SSI1,TIP3
- Gene Description:
- suppressor of cytokine signaling 1
- Omim ID:
- 603597
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq
- Other Designations:
- JAK binding protein,STAT induced SH3 protein 1,Tec-interacting protein 3,cytokine-inducible SH2 protein 1
- Entrez GeneID:
- 12703
- Gene Name:
- Socs1
- Gene Alias:
- Cish1,Cish7,JAB,SOCS-1,SSI-1
- Gene Description:
- suppressor of cytokine signaling 1
- Gene Ontology:
- Hyperlink
- Other Designations:
- JAK-binding protein,JAK2-binding protein,STAT-induced STAT inhibitor 1,cytokine inducible SH2-containing protein 1,cytokine inducible SH2-containing protein 7