BAX polyclonal antibody
产品名称： BAX polyclonal antibody
英文名称： BAX polyclonal antibody
产品编号： PAB12927
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of BAX.
- Immunogen:
- A synthetic peptide corresponding to N-terminus 16 amino acids of human BAX.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Storage Buffer:
- In PBS (0.02% sodium azide)
- Storage Instruction:
- Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- The Bcl-2 protein family and its role in the development of neoplastic disease.
Heiser D, Labi V, Erlacher M, Villunger A.Exp Gerontol. 2004 Aug;39(8):1125-35.
- 2.
- The Bcl-2 family: roles in cell survival and oncogenesis.
Cory S, Huang DC, Adams JM.Oncogene. 2003 Nov 24;22(53):8590-607.
- 3.
- Cell death in the third millennium.
Lockshin RA, Osborne B, Zakeri Z.Cell Death Differ. 2000 Jan;7(1):2-7.
- Entrez GeneID:
- 581
- Protein Accession#:
- AAA03619
- Gene Name:
- BAX
- Gene Alias:
- BCL2L4
- Gene Description:
- BCL2-associated X protein
- Omim ID:
- 600040
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq
- Other Designations:
- apoptosis regulator BAX
- Interactome
- Related Disease
- Adenocarcinoma
- Ataxia Telangiectasia
- Carcinoma, Squamous Cell
- Cardiovascular Diseases
- Colon cancer
- Colonic Neoplasms
- Diabetes Mellitus, Type 2
- Disease Progression
- Edema
- Esophageal Neoplasms
- Genetic Predisposition to Disease
- Genomic Instability
- Head and Neck Neoplasms
- Helicobacter Infections
- Hematologic Diseases
- Hodgkin Disease
- Kidney Failure, Chronic
- Leukemia, chronic myeloid
- Leukemia, Lymphocytic, Chronic