RELA (phospho S536) Peptide
产品名称: RELA (phospho S536) Peptide
英文名称: RELA (phospho S536) Peptide
产品编号: P1360
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of RELA.
- Immunogen:
- Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S536 of human RELA.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Recruitment of NF-kappaB into mitochondria is involved in adenine nucleotide translocase 1 (ANT1)-induced apoptosis.
Zamora M, Merono C, Vinas O, Mampel T.J Biol Chem. 2004 Sep 10;279(37):38415-23. Epub 2004 Jul 1.
- 2.
- HTLV-I Tax induces a novel interaction between p65/RelA and p53 that results in inhibition of p53 transcriptional activity.
Jeong SJ, Radonovich M, Brady JN, Pise-Masison CA.Blood. 2004 Sep 1;104(5):1490-7. Epub 2004 May 20.
- 3.
- p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.
Bohuslav J, Chen LF, Kwon H, Mu Y, Greene WC.J Biol Chem. 2004 Jun 18;279(25):26115-25. Epub 2004 Apr 8.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of RELA (phospho S536) polyclonal antibody (Cat # PAB0546) in mouse kidney tissue lysates (35 ug/lane). RELA (arrow) was detected using the purified Pab.
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human cancer tissue reacted with RELA (phospho S536) polyclonal antibody (Cat # PAB0546) which was peroxidase-conjugated to the secondary antibody followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.
- Entrez GeneID:
- 5970
- Protein Accession#:
- NP_068810;Q04206
- Gene Name:
- RELA
- Gene Alias:
- MGC131774,NFKB3,p65
- Gene Description:
- v-rel reticuloendotheliosis viral oncogene homolog A (avian)
- Omim ID:
- 164014
- Gene Ontology:
- Hyperlink
- Gene Summary:
- NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL (MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form of NFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NFKB complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM
- Other Designations:
- nuclear factor of kappa light polypeptide gene enhancer in B-cells 3,v-rel avian reticuloendotheliosis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 (p65)),v-rel reticuloendotheliosis viral oncogene homolog
- Gene Pathway
- Acute myeloid leukemia
- Adipocytokine signaling pathway
- Apoptosis
- B cell receptor signaling pathway
- Chemokine signaling pathway
- Chronic myeloid leukemia
- Epithelial cell signaling in Helicobacter pylori infection
- MAPK signaling pathway
- Neurotrophin signaling pathway
- Pancreatic cancer
- Pathways in cancer
- Prostate cancer
- Small cell lung cancer
- T cell receptor signaling pathway
- Toll-like receptor signaling pathway
- Related Disease
- Arthritis, Rheumatoid
- Breast cancer
- Breast Neoplasms
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Disease Progression
- Disease Susceptibility
- Edema
- Genetic Predisposition to Disease
- Hematologic Diseases
- HIV Infections
- Hodgkin Disease
- Liver Cirrhosis
- Lymphoproliferative Disorders
- Multiple Myeloma
- Occupational Diseases
- Testicular Neoplasms
- Waldenstrom Macroglobulinemia
- Werner syndrome