FKBP8 polyclonal antibody
产品名称： FKBP8 polyclonal antibody
英文名称： FKBP8 polyclonal antibody
产品编号： PAB10013
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of FKBP8.
- Immunogen:
- A synthetic peptide corresponding to internal region of human FKBP8.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Storage Buffer:
- In 20 mM KH2PO4, 150 mM NaCl, pH 7.2 (0.01% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- ELISA (1:25000)
Western Blot (1:500-1:2000)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression.
Portier BP, Taglialatela G.J Biol Chem. 2006 Dec 29;281(52):40493-502. Epub 2006 Nov 7.
- 2.
- Hepatitis C virus RNA replication is regulated by FKBP8 and Hsp90.
Okamoto T, Nishimura Y, Ichimura T, Suzuki K, Miyamura T, Suzuki T, Moriishi K, Matsuura Y.EMBO J. 2006 Oct 18;25(20):5015-25. Epub 2006 Oct 5.
- 3.
- Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells.
Wang J, Tong W, Zhang X, Chen L, Yi Z, Pan T, Hu Y, Xiang L, Yuan Z.FEBS Lett. 2006 Aug 7;580(18):4392-400. Epub 2006 Jul 17.
- Applications
- Western Blot
- Western blot using FKBP8 polyclonal antibody (Cat # PAB10013) shows detection of exogenous FKBP8 in 50 ug of HEK293T whole cell lysate (Lane 1).
The results of peptide competition are shown in lane 2 where no specific staining is noted after the antibody is first incubated for 1h with the immunizing peptide in 5% BLOTTO prior to reaction with the membrane.
The membrane was probed with the primary antibody at a 1 : 1,000 dilution in 5% BLOTTO at 4°C, overnight.
Personal Communication, Olga Aprelikova, CCR-NCI, Bethesda, MD.
- Entrez GeneID:
- 23770
- Protein Accession#:
- NP_036313;Q86YK6
- Gene Name:
- FKBP8
- Gene Alias:
- FKBP38,FKBPr38
- Gene Description:
- FK506 binding protein 8, 38kDa
- Omim ID:
- 604840
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq
- Other Designations:
- FK506 binding protein 8 (38kD),FK506-binding protein 8,FK506-binding protein 8 (38kD)