PTPN1 Assay Kit
产品名称: PTPN1 Assay Kit
英文名称: PTPN1 Assay Kit
产品编号: KA0905
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- PTPN1 Assay Kit is used for detecting enzyme activity and screening phosphatase 1B (PTP1B).
- Reactivity:
- Mammals
- Storage Instruction:
- Store the kit at -20°C.
- Protocol:
- Protocol Download
- MSDS:
- Download
- Detection Method:
- Fluorometric
- Regulation Status:
- For research use only (RUO)
- Application Image
- Functional Study
- Entrez GeneID:
- 5770
- Gene Name:
- PTPN1
- Gene Alias:
- PTP1B
- Gene Description:
- protein tyrosine phosphatase, non-receptor type 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq
- Other Designations:
- OTTHUMP00000031266,non-receptor tyrosine phosphatase 1,protein tyrosine phosphatase 1B,protein tyrosine phosphatase, placental
- Gene Pathway
- Related Disease
- Albuminuria
- Alzheimer Disease
- Alzheimer disease
- Arteriosclerosis
- Atherosclerosis
- Atherosclerosis
- Atrophy
- Calcinosis
- Cardiomyopathy, Hypertrophic
- Cardiovascular Diseases
- Cerebrovascular Disorders
- Coronary Artery Disease
- Coronary Disease
- Diabetes Complications
- Diabetes Mellitus
- Diabetes Mellitus, Type 2
- Diabetic Angiopathies
- Diabetic Retinopathy
- Dyslipidemias