ROCK1 polyclonal antibody
产品名称： ROCK1 polyclonal antibody
英文名称： ROCK1 polyclonal antibody
产品编号： PAB2021
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of ROCK1.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human ROCK1.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition.
Mammoto A, Huang S, Moore K, Oh P, Ingber DE.J Biol Chem. 2004 Jun 18;279(25):26323-30. Epub 2004 Apr 19.
- 2.
- Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase.
Oi K, Shimokawa H, Hiroki J, Uwatoku T, Abe K, Matsumoto Y, Nakajima Y, Nakajima K, Takeichi S, Takeshita A.Arterioscler Thromb Vasc Biol. 2004 May;24(5):918-22. Epub 2004 Mar 25.
- 3.
- Enhancement of migration and invasion of hepatoma cells via a Rho GTPase signaling pathway.
Wang DS, Dou KF, Li KZ, Song ZS.World J Gastroenterol. 2004 Jan 15;10(2):299-302.
- Entrez GeneID:
- 6093
- Protein Accession#:
- NP_005397;Q13464
- Gene Name:
- ROCK1
- Gene Alias:
- MGC131603,MGC43611,P160ROCK,PRO0435
- Gene Description:
- Rho-associated, coiled-coil containing protein kinase 1
- Omim ID:
- 601702
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq
- Other Designations:
- OTTHUMP00000162514,p160-ROCK
- Related Disease
- Adenocarcinoma
- Cardiovascular Diseases
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- HIV Infections
- Obesity
- Ovarian Failure, Premature
- Pancreatic Neoplasms
- Polycystic Ovary Syndrome
- Puberty, Delayed
- Puberty, Precocious
- Schizophrenia
- Schizophrenia
- Thrombophilia
- Tobacco Use Disorder